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Preparation of a 1,2-isoxazolidine synthon for the synthesis of zetekitoxin AB
A synthesis of the 1,2-isoxazolidine fragment of the potent voltage gated sodium channel blocker, zetekitoxin AB is described. The synthesis utilizes an intramolecular nitrone –olefin 1,3-dipolar cycloaddition to establish the stereochemistry of the cis-1,2-isoxazolidine. The oxidative cleavage of a...
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| Publicado no: | Tetrahedron Lett |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4649947/ https://ncbi.nlm.nih.gov/pubmed/26594065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.09.070 |
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