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Differential immunogenicity between HAdV-5 and chimpanzee adenovirus vector ChAdOx1 is independent of fiber and penton RGD loop sequences in mice

Replication defective adenoviruses are promising vectors for the delivery of vaccine antigens. However, the potential of a vector to elicit transgene-specific adaptive immune responses is largely dependent on the viral serotype used. HAdV-5 (Human adenovirus C) vectors are more immunogenic than chim...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Dicks, Matthew D. J., Spencer, Alexandra J., Coughlan, Lynda, Bauza, Karolis, Gilbert, Sarah C., Hill, Adrian V. S., Cottingham, Matthew G.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649739/
https://ncbi.nlm.nih.gov/pubmed/26576856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16756
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