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p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis
Phagocytosis of SiO(2) into the lung causes an inflammatory cascade that results in fibroblast proliferation and migration, followed by fibrosis. Clinical evidence has indicated that the activation of alveolar macrophages by SiO(2) produces rapid and sustained inflammation characterized by the gener...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4649630/ https://ncbi.nlm.nih.gov/pubmed/26576741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16900 |
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