LAG-3 and 4-1BB identify dysfunctional antigen-specific T cells in the tumor microenvironment and combinatorial LAG-3/4-1BB targeting gives synergistic tumor control

Ähnliche Einträge

• The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8(+) T cells in the tumor microenvironment
  von: Williams, Jason B., et al.
  Veröffentlicht: (2017)
• Agonistic 4-1bb antibodies in combination with inhibitory antibodies against CTLA-4, PD-L1 or LAG-3 ACT on CD8+ T cells in the tumor microenvironment and synergize to promote regression of established tumors
  von: Horton, Brendan, et al.
  Veröffentlicht: (2014)
• Agonist anti-4-1BB plus neutralizing anti-CTLA-4 or -PD-L1 synergize to promote tumor regression by rescuing dying dysfunctional CD8+ T cells within the tumor microenvironment
  von: Horton, Brendan, et al.
  Veröffentlicht: (2015)
• Synergistic PD‐1/LAG‐3 Inhibition: Mechanistic Insights and Implications for Enhanced Tumor Immunotherapy
  von: Jianqiao Shentu, et al.
  Veröffentlicht: (2025-06-01)
• Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment
  von: Spranger, Stefani, et al.
  Veröffentlicht: (2014)