Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells

Self-renewal potential and multipotency are hallmarks of a stem cell. It is generally accepted that acquisition of such stemness requires rejuvenation of somatic cells through reprogramming of their genetic and epigenetic status. We show here that a simple block of cell differentiation is sufficient...

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Udgivet i:Stem Cell Reports
Main Authors: Ikawa, Tomokatsu, Masuda, Kyoko, Huijskens, Mirelle J.A.J., Satoh, Rumi, Kakugawa, Kiyokazu, Agata, Yasutoshi, Miyai, Tomohiro, Germeraad, Wilfred T.V., Katsura, Yoshimoto, Kawamoto, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649263/
https://ncbi.nlm.nih.gov/pubmed/26607950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.09.012
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