Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions

This study investigated the antibacterial activity of the plant alkaloid tomatidine (TO) against Staphylococcus aureus grown in the presence of Pseudomonas aeruginosa. Since the P. aeruginosa exoproduct 4-hydroxy-2-heptylquinoline-N-oxide (HQNO) is known to cause a respiratory deficiency in S. aureu...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Boulanger, Simon, Mitchell, Gabriel, Bouarab, Kamal, Marsault, Éric, Cantin, André, Frost, Eric H., Déziel, Eric, Malouin, François
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649251/
https://ncbi.nlm.nih.gov/pubmed/26392496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01711-15
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