Multiple Genetic Mutations Associated with Polymyxin Resistance in Acinetobacter baumannii

We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates....

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Lim, Tze Peng, Ong, Rick Twee-Hee, Hon, Pei-Yun, Hawkey, Jane, Holt, Kathryn E., Koh, Tse Hsien, Leong, Micky Lo-Ngah, Teo, Jocelyn Qi-Min, Tan, Thean Yen, Ng, Mary Mah-Lee, Hsu, Li Yang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649193/
https://ncbi.nlm.nih.gov/pubmed/26438500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01884-15
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