Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

Frequent activation of phosphatidylinositol-3 kinases (PI3K)/Akt/mTOR signaling pathway in gastric cancer (GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3CA gene or loss of function of PTEN, a tumor suppressor protein, to name a few; both playing a cr...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Singh, Shikha Satendra, Yap, Wei Ney, Arfuso, Frank, Kar, Shreya, Wang, Chao, Cai, Wanpei, Dharmarajan, Arunasalam M, Sethi, Gautam, Kumar, Alan Prem
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649111/
https://ncbi.nlm.nih.gov/pubmed/26604635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i43.12261
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