Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer

Irinotecan hydrochloride is a camptothecin derivative that exerts antitumor activity against a variety of tumors. SN-38 produced in the body by carboxylesterase is the active metabolite of irinotecan. After irinotecan was introduced for the treatment of metastatic colorectal cancer (CRC) at the end...

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Fujita, Ken-ichi, Kubota, Yutaro, Ishida, Hiroo, Sasaki, Yasutsuna
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649109/
https://ncbi.nlm.nih.gov/pubmed/26604633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i43.12234
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