Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease

Selenium (Se) is essential for both brain development and male fertility. Male mice lacking two key genes involved in Se metabolism (Scly(−/−)Sepp1(−/−) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures that manif...

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Pubblicato in:J Neurosci
Autori principali: Pitts, Matthew W., Kremer, Penny M., Hashimoto, Ann C., Torres, Daniel J., Byrns, China N., Williams, Christopher S., Berry, Marla J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649005/
https://ncbi.nlm.nih.gov/pubmed/26586820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2724-15.2015
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