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Guanosine inhibits LPS-induced pro-inflammatory response and oxidative stress in hippocampal astrocytes through the heme oxygenase-1 pathway

Guanosine, a guanine-based purine, is an extracellular signaling molecule that is released from astrocytes and has been shown to promote central nervous system defenses in several in vivo and in vitro injury models. Our group recently demonstrated that guanosine exhibits glioprotective effects in th...

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Publicat a:Purinergic Signal
Autors principals: Bellaver, Bruna, Souza, Débora Guerini, Bobermin, Larissa Daniele, Gonçalves, Carlos-Alberto, Souza, Diogo Onofre, Quincozes-Santos, André
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648801/
https://ncbi.nlm.nih.gov/pubmed/26431832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-015-9475-2
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