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BRAF inhibition generates a host/tumor niche that mediates therapeutic escape
The current study defines a fibroblast-derived niche that facilitates the therapeutic escape of melanoma cells from BRAF inhibition. Vemurafenib treatment led to the release of TGF-β from the melanoma cells that increased the differentiation state of the fibroblasts; an affect associated with fibron...
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| Publicat a: | J Invest Dermatol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4648653/ https://ncbi.nlm.nih.gov/pubmed/26302068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2015.329 |
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