Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits

Signaling from the epidermal growth factor receptor (EGFR) via phosphorylation on its C-terminal tyrosine residues requires self-association, which depends on the diffusional properties of the receptor and its density in the plasma membrane. Dimerization is a key event for EGFR activation, but the r...

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Publicat a:PLoS One
Autors principals: Ibach, Jenny, Radon, Yvonne, Gelléri, Márton, Sonntag, Michael H., Brunsveld, Luc, Bastiaens, Philippe I. H., Verveer, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648588/
https://ncbi.nlm.nih.gov/pubmed/26575183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143162
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