ACD toxin-produced actin oligomers poison formin-controlled actin polymerization

The actin crosslinking domain (ACD) is an actin-specific toxin produced by several pathogens, including life-threatening spp. of Vibrio cholerae, Vibrio vulnificus, and Aeromonas hydrophila. Actin crosslinking by ACD is thought to lead to slow cytoskeleton failure owing to a gradual sequestration of...

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Foilsithe in:Science
Main Authors: Heisler, David B., Kudryashova, Elena, Grinevich, Dmitry O., Suarez, Cristian, Winkelman, Jonathan D., Birukov, Konstantin G., Kotha, Sainath R., Parinandi, Narasimham L., Vavylonis, Dimitrios, Kovar, David R., Kudryashov, Dmitri S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648357/
https://ncbi.nlm.nih.gov/pubmed/26228148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab4090
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