Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio

Isocitrate dehydrogenase-1 (Idh1) is an important metabolic enzyme that produces NADPH by converting isocitrate to α-ketoglutarate. Idh1 is known to reduce reactive oxygen species (ROS) induced in cells by treatment with lipopolysaccharide (LPS) in vitro. Here, we used Idh1-deficient knockout (Idh1...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Itsumi, M, Inoue, S, Elia, A J, Murakami, K, Sasaki, M, Lind, E F, Brenner, D, Harris, I S, Chio, I I C, Afzal, S, Cairns, R A, Cescon, D W, Elford, A R, Ye, J, Lang, P A, Li, W Y, Wakeham, A, Duncan, G S, Haight, J, You-Ten, A, Snow, B, Yamamoto, K, Ohashi, P S, Mak, T W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648331/
https://ncbi.nlm.nih.gov/pubmed/25882048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.38
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