Ryanodine receptor cluster fragmentation and redistribution in persistent atrial fibrillation enhance calcium release

AIMS: In atrial fibrillation (AF), abnormalities in Ca(2+) release contribute to arrhythmia generation and contractile dysfunction. We explore whether ryanodine receptor (RyR) cluster ultrastructure is altered and is associated with functional abnormalities in AF. METHODS AND RESULTS: Using high-res...

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Vydáno v:Cardiovasc Res
Hlavní autoři: Macquaide, Niall, Tuan, Hoang-Trong Minh, Hotta, Jun-ichi, Sempels, Wouter, Lenaerts, Ilse, Holemans, Patricia, Hofkens, Johan, Jafri, M. Saleet, Willems, Rik, Sipido, Karin R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
ORIGINAL ARTICLES
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648199/
https://ncbi.nlm.nih.gov/pubmed/26490742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv231
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