Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B

AIM: Alpha7-nicotinic acetylcholine receptor (α7 nAChR) is a ligand-gated Ca(2+)-permeable ion channel implicated in cognition and neuropsychiatric disorders. Activation of α7 nAChR improves learning, memory, and sensory gating in animal models. To identify novel α7 nAChR agonists, we synthesized a...

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Publicado no:Acta Pharmacol Sin
Main Authors: Tang, Jing-shu, Xie, Bing-xue, Bian, Xi-ling, Xue, Yu, Wei, Ning-ning, Zhou, Jing-heng, Hao, Yu-chen, Li, Gang, Zhang, Liang-ren, Wang, Ke-wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648113/
https://ncbi.nlm.nih.gov/pubmed/25948478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.9
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