Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes

PTEN is a dual-specificity protein tyrosine phosphatase. As one of the central tumor suppressors, a thorough regulation of its activity is essential for proper cellular homeostasis. The precise implications of PTEN inhibition by reactive oxygen species (e.g. H(2)O(2)) and the subsequent structural c...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Lee, Chang-Uk, Hahne, Gernot, Hanske, Jonas, Bange, Tanja, Bier, David, Rademacher, Christoph, Hennig, Sven, Grossmann, Tom N
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2015
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648047/
https://ncbi.nlm.nih.gov/pubmed/26418532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201506338
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