NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides

The efficient asymmetric synthesis of highly substituted succinimides from α,β-unsaturated aldehydes and α-ketoamides via NHC-catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles and provides...

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Bibliographic Details
Published in:Chemistry
Main Authors: Wang, Lei, Ni, Qijian, Blümel, Marcus, Shu, Tao, Raabe, Gerhard, Enders, Dieter
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2015
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648042/
https://ncbi.nlm.nih.gov/pubmed/25877658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201500661
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