Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor.

Structure-activity studies demonstrate that galanin fragments 1-15 and 2-29 are fully active, whereas fragment 3-29 has been reported to be inactive, in a number of different in vivo models. M15, a chimeric peptide comprising galanin 1-13 and substance P5-11, has recently been found to be a potent g...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Wynick, D, Smith, D M, Ghatei, M, Akinsanya, K, Bhogal, R, Purkiss, P, Byfield, P, Yanaihara, N, Bloom, S R
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1993
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7683428/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.9.4231
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