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Dichotomizing partial compliance and increased participant burden in factorial designs: the performance of four noncompliance methods

BACKGROUND: Noncompliance to treatment assignment is an inevitable occurrence in randomized clinical trials (RCTs). Intention to treat (ITT) is generally considered the best method for addressing noncompliance in RCTs. Alternatives to ITT exist, including per protocol (PP), as treated (AT), and inst...

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Merrill, Peter D., McClure, Leslie A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647702/
https://ncbi.nlm.nih.gov/pubmed/26573840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-1044-z
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