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Dichotomizing partial compliance and increased participant burden in factorial designs: the performance of four noncompliance methods

BACKGROUND: Noncompliance to treatment assignment is an inevitable occurrence in randomized clinical trials (RCTs). Intention to treat (ITT) is generally considered the best method for addressing noncompliance in RCTs. Alternatives to ITT exist, including per protocol (PP), as treated (AT), and inst...

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Publicat a:Trials
Autors principals: Merrill, Peter D., McClure, Leslie A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647702/
https://ncbi.nlm.nih.gov/pubmed/26573840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-1044-z
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