Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers

BACKGROUND: RAS wild-type (RAS(w/t)) tumours have been associated with better outcomes in patients with metastatic colorectal cancer (mCRC) treated with anti-EGFR monoclonal antibodies (mAb). We investigated the expression of EGFR downstream proteins under their active phosphorylated forms as potent...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Cancer
Hauptverfasser: Harlé, A, Salleron, J, Perkins, G, Pilati, C, Blons, H, Laurent-Puig, P, Merlin, J L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Molecular Diagnostics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647679/
https://ncbi.nlm.nih.gov/pubmed/26171935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.250
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