Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton

BACKGROUND: The recent identification of several mutations in PFN1, a protein involved in actin dynamics, strengthens the hypothesis that pathology of amyotrophic lateral sclerosis is linked to cytoskeletal defects. Impaired actin binding is a common denominator of several PFN1 mutations associated...

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Pubblicato in:BMC Neurosci
Autori principali: Freischmidt, Axel, Schöpflin, Marcel, Feiler, Marisa S., Fleck, Ann-Katrin, Ludolph, Albert C., Weishaupt, Jochen H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647582/
https://ncbi.nlm.nih.gov/pubmed/26572741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-015-0214-y
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