Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack

BACKGROUND: The angiopoietin/Tie2 pathway is an attractive target for cancer therapy due to its well-known role in regulating angiogenesis. Trebananib, a recombinant peptide-Fc fusion protein, or peptibody, that binds to angiopoietin-1 (Ang1) and Ang2 to block their interaction with the Tie2 recepto...

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Detaylı Bibliyografya
Yayımlandı:J Immunother Cancer
Asıl Yazarlar: Grenga, Italia, Kwilas, Anna R., Donahue, Renee N., Farsaci, Benedetto, Hodge, James W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647578/
https://ncbi.nlm.nih.gov/pubmed/26579226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-015-0096-7
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