A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence

Polycomb-like proteins 1–3 (PCL1–3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such apparent functional redundancy exist in mammals. Here we charact...

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Udgivet i:Genes Dev
Main Authors: Brien, Gerard L., Healy, Evan, Jerman, Emilia, Conway, Eric, Fadda, Elisa, O'Donovan, Darragh, Krivtsov, Andrei V., Rice, Alan M., Kearney, Conor J., Flaus, Andrew, McDade, Simon S., Martin, Seamus J., McLysaght, Aoife, O'Connell, David J., Armstrong, Scott A., Bracken, Adrian P.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647557/
https://ncbi.nlm.nih.gov/pubmed/26494712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.267930.115
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