A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence

Polycomb-like proteins 1–3 (PCL1–3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such apparent functional redundancy exist in mammals. Here we charact...

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Pubblicato in:Genes Dev
Autori principali: Brien, Gerard L., Healy, Evan, Jerman, Emilia, Conway, Eric, Fadda, Elisa, O'Donovan, Darragh, Krivtsov, Andrei V., Rice, Alan M., Kearney, Conor J., Flaus, Andrew, McDade, Simon S., Martin, Seamus J., McLysaght, Aoife, O'Connell, David J., Armstrong, Scott A., Bracken, Adrian P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647557/
https://ncbi.nlm.nih.gov/pubmed/26494712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.267930.115
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