Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas

BACKGROUND: Human sarcomas with a poor response to vascular endothelial growth factor-A (VEGF-A) inhibition and radiation therapy (RT) have upregulation of hypoxia-inducible factor 1α (HIF-1α) and HIF-1α target genes. This study examines the addition of the hypoxia-activated chemotherapy TH-302 to V...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Yoon, C, Lee, H-J, Park, D J, Lee, Y-J, Tap, W D, Eisinger-Mathason, T S K, Hart, C P, Choy, E, Simon, M C, Yoon, S S
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647529/
https://ncbi.nlm.nih.gov/pubmed/26010414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.186
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