Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis

Retinitis pigmentosa (RP) is a rare genetic disease that causes gradual blindness through retinal degeneration. Intriguingly, seven of the 24 genes identified as responsible for the autosomal-dominant form (adRP) are ubiquitous spliceosome components whose impairment causes disease only in the retin...

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Vydáno v:RNA
Hlavní autoři: Rubio-Peña, Karinna, Fontrodona, Laura, Aristizábal-Corrales, David, Torres, Silvia, Cornes, Eric, García-Rodríguez, Francisco J., Serrat, Xènia, González-Knowles, David, Foissac, Sylvain, Porta-De-La-Riva, Montserrat, Cerón, Julián
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647465/
https://ncbi.nlm.nih.gov/pubmed/26490224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.053397.115
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