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Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion

Integrins play crucial roles in epithelial adhesion, proliferation, wound healing and cancer. In the epidermis, the roles of many integrin subunits are incompletely defined and mechanistic details regarding their functions are lacking. We performed a multiplexed small hairpin (sh)RNA screen to defin...

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Sci
Hauptverfasser: Duperret, Elizabeth K., Dahal, Ankit, Ridky, Todd W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647167/
https://ncbi.nlm.nih.gov/pubmed/26359297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.175539
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