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Cell-Type Specific Channelopathies in the Prefrontal Cortex of the fmr1-/y Mouse Model of Fragile X Syndrome(1,2,3)

Fragile X syndrome (FXS) is caused by transcriptional silencing of the fmr1 gene resulting in the loss of fragile X mental retardation protein (FMRP) expression. FXS patients display several behavioral phenotypes associated with prefrontal cortex (PFC) dysfunction. Voltage-gated ion channels, some o...

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Publicat a:eNeuro
Autors principals: Kalmbach, Brian E., Johnston, Daniel, Brager, Darrin H.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647062/
https://ncbi.nlm.nih.gov/pubmed/26601124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0114-15.2015
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