Replication and Extension of Association Between Common Genetic Variants in SIM1 and Human Adiposity

Haplo-insufficiency of the bHLH (basic helix-loop-helix) transcription factor single-minded 1 (SIM1) causes severe obesity in mice and humans. We hypothesized that common genetic variations in/near SIM1 could exert more subtle effects on its function and associate with human adiposity. First, SIM1 c...

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Publicat a:Obesity (Silver Spring)
Autors principals: Swarbrick, Michael M., Evans, Daniel S., Valle, Maria. I., Favre, Hélène, Wu, Shi-Hsuan, Njajou, Omer T., Li, Rongling, Zmuda, Joseph M., Miljkovic, Iva, Harris, Tamara B., Kwok, Pui-Yan, Vaisse, Christian, Hsueh, Wen-Chi
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646950/
https://ncbi.nlm.nih.gov/pubmed/21512513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oby.2011.79
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