Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s Disease

Paget’s disease of bone (PDB) is a common disease characterized by osteoclast activation that leads to various skeletal complications. Susceptibility to PDB is mediated by a common variant at the optineurin (OPTN) locus, which is associated with reduced levels of mRNA. However, it is unclear how thi...

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Publicat a:Cell Rep
Autors principals: Obaid, Rami, Wani, Sachin E., Azfer, Asim, Hurd, Toby, Jones, Ruth, Cohen, Philip, Ralston, Stuart H., Albagha, Omar M.E.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2015
Matèries:
Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646838/
https://ncbi.nlm.nih.gov/pubmed/26527009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.071
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