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Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase
Antigen-specific immune responses to protein drugs can hinder efficacy and compromise safety because of drug neutralization and secondary clinical complications. We report a tolerance induction strategy to prevent antigen-specific humoral immune responses to therapeutic proteins. Our modular, biomol...
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| Publicado en: | Sci Adv |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Association for the Advancement of Science
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646778/ https://ncbi.nlm.nih.gov/pubmed/26601215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500112 |
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