Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model

No clinically applicable drug is currently available to enhance neurite elongation after nerve injury. To identify a clinically applicable drug, we screened pre-approved drugs for neurite elongation in the motor neuron-like NSC34 cells. We found that zonisamide, an anti-epileptic and anti-Parkinson’...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yagi, Hideki, Ohkawara, Bisei, Nakashima, Hiroaki, Ito, Kenyu, Tsushima, Mikito, Ishii, Hisao, Noto, Kimitoshi, Ohta, Kyotaro, Masuda, Akio, Imagama, Shiro, Ishiguro, Naoki, Ohno, Kinji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646494/
https://ncbi.nlm.nih.gov/pubmed/26571146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142786
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