Decreased nicotinic receptor availability in smokers with slow rates of nicotine metabolism

The nicotine metabolite ratio (NMR), a stable measure of hepatic nicotine metabolism via the CYP2A6 pathway and total nicotine clearance, is a predictive biomarker of response to nicotine replacement therapy, with increased quit rates in slower metabolizers. Nicotine binds directly to nicotinic acet...

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Pubblicato in:J Nucl Med
Autori principali: Dubroff, Jacob G., Doot, Robert K., Falcone, Mary, R, Robert A. Schnoll, Ray, Riju, Tyndale, Rachel F., Brody, Arthur L., Hou, Catherine, Schmitz, Alexander, Lerman, Caryn
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646418/
https://ncbi.nlm.nih.gov/pubmed/26272810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.115.155002
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