Cystatin D Locates in the Nucleus at Sites of Active Transcription and Modulates Gene and Protein Expression

Cystatin D is an inhibitor of lysosomal and secreted cysteine proteases. Strikingly, cystatin D has been found to inhibit proliferation, migration, and invasion of colon carcinoma cells indicating tumor suppressor activity that is unrelated to protease inhibition. Here, we demonstrate that a proport...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Ferrer-Mayorga, Gemma, Alvarez-Díaz, Silvia, Valle, Noelia, De Las Rivas, Javier, Mendes, Marta, Barderas, Rodrigo, Canals, Francesc, Tapia, Olga, Casal, J. Ignacio, Lafarga, Miguel, Muñoz, Alberto
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646312/
https://ncbi.nlm.nih.gov/pubmed/26364852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.660175
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