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Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3)

The NFE2L3 transcription factor has been implicated in various cellular processes, including carcinogenesis, stress response, differentiation, and inflammation. Previously it has been shown that NFE2L3 has a rapid turnover and is stabilized by proteasomal inhibitors. The mechanisms regulating the de...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Kannan, Meenakshi B., Dodard-Friedman, Isadore, Blank, Volker
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646277/
https://ncbi.nlm.nih.gov/pubmed/26306035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666446
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