Evidence of Distinct Channel Conformations and Substrate Binding Affinities for the Mitochondrial Outer Membrane Protein Translocase Pore Tom40

Nearly all mitochondrial proteins are coded by the nuclear genome and must be transported into mitochondria by the translocase of the outer membrane complex. Tom40 is the central subunit of the translocase complex and forms a pore in the mitochondrial outer membrane. To date, the mechanism it utiliz...

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Foilsithe in:J Biol Chem
Main Authors: Kuszak, Adam J., Jacobs, Daniel, Gurnev, Philip A., Shiota, Takuya, Louis, John M., Lithgow, Trevor, Bezrukov, Sergey M., Rostovtseva, Tatiana K., Buchanan, Susan K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646270/
https://ncbi.nlm.nih.gov/pubmed/26336107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642173
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