The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase

The dNTP triphosphohydrolase SAMHD1 is a nuclear antiviral host restriction factor limiting HIV-1 infection in macrophages and a major regulator of dNTP concentrations in human cells. In normal human fibroblasts its expression increases during quiescence, contributing to the small dNTP pool sizes of...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Franzolin, Elisa, Salata, Cristiano, Bianchi, Vera, Rampazzo, Chiara
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
Onderwerpen:
DNA and Chromosomes
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646252/
https://ncbi.nlm.nih.gov/pubmed/26342080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.675082
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