ATM Inhibition Potentiates Death of Androgen Receptor-inactivated Prostate Cancer Cells with Telomere Dysfunction

Androgen receptor (AR) plays a role in maintaining telomere stability in prostate cancer cells, as AR inactivation induces telomere dysfunction within 3 h. Since telomere dysfunction in other systems is known to activate ATM (ataxia telangiectasia mutated)-mediated DNA damage response (DDR) signalin...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Reddy, Vidyavathi, Wu, Min, Ciavattone, Nicholas, McKenty, Nathan, Menon, Mani, Barrack, Evelyn R., Reddy, G. Prem-Veer, Kim, Sahn-Ho
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646198/
https://ncbi.nlm.nih.gov/pubmed/26336104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.671404
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