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Potassium channels related to primary aldosteronism: expression similarities and differences between human and rat adrenals

Three potassium channels have been associated with primary aldosteronism (PA) in rodents and humans: KCNK3 (TASK-1), KCNK9 (TASK-3), and KCNJ5 (Kir3.4). Mice with deficiency in Kcnk3 and Kcnk9 have elevated aldosterone production and blood pressure. In humans, adrenal tumors with somatic mutations i...

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書誌詳細
出版年:Mol Cell Endocrinol
主要な著者: Chen, Andrew X., Nishimoto, Koshiro, Nanba, Kazutaka, Rainey, William E.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646165/
https://ncbi.nlm.nih.gov/pubmed/26375812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2015.09.011
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