High Concentrations of Drug in Target Tissues Following Local Controlled Release Are Utilized for Both Drug Distribution and Biologic Effect: An Example with Epicardial Inotropic Drug Delivery

Local drug delivery preferentially loads target tissues with a concentration gradient from the surface or point of release that tapers down to more distant sites. Drug that diffuses down this gradient must be in unbound form, but such drug can only elicit a biologic effect through receptor interacti...

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Veröffentlicht in:J Control Release
Hauptverfasser: Maslov, Mikhail Y., Edelman, Elazer R., Wei, Abraham E., Pezone, Matthew J., Lovich, Mark A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646071/
https://ncbi.nlm.nih.gov/pubmed/23872515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.06.038
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