Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein

Sendai virus (SeV) C protein inhibits the signal transduction pathways of interferon alpha/beta (IFN-α/β) and IFN-γ by binding to the N-terminal domain of STAT1 (STAT1ND), thereby allowing SeV to escape from host innate immunity. Here we determined the crystal structure of STAT1ND associated with th...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Oda, Kosuke, Matoba, Yasuyuki, Irie, Takashi, Kawabata, Ryoko, Fukushi, Masaya, Sugiyama, Masanori, Sakaguchi, Takemasa
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645678/
https://ncbi.nlm.nih.gov/pubmed/26339056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01887-15
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