CD8(+) T Cell Exhaustion, Suppressed Gamma Interferon Production, and Delayed Memory Response Induced by Chronic Brucella melitensis Infection

Brucella melitensis is a well-adapted zoonotic pathogen considered a scourge of mankind since recorded history. In some cases, initial infection leads to chronic and reactivating brucellosis, incurring significant morbidity and economic loss. The mechanism by which B. melitensis subverts adaptive im...

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Detalles Bibliográficos
Publicado en:Infect Immun
Autores principales: Durward-Diioia, Marina, Harms, Jerome, Khan, Mike, Hall, Cherisse, Smith, Judith A., Splitter, Gary A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645381/
https://ncbi.nlm.nih.gov/pubmed/26416901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01184-15
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