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CD8(+) T Cell Exhaustion, Suppressed Gamma Interferon Production, and Delayed Memory Response Induced by Chronic Brucella melitensis Infection

Brucella melitensis is a well-adapted zoonotic pathogen considered a scourge of mankind since recorded history. In some cases, initial infection leads to chronic and reactivating brucellosis, incurring significant morbidity and economic loss. The mechanism by which B. melitensis subverts adaptive im...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Durward-Diioia, Marina, Harms, Jerome, Khan, Mike, Hall, Cherisse, Smith, Judith A., Splitter, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645381/
https://ncbi.nlm.nih.gov/pubmed/26416901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01184-15
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