CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia

Patients with chemo-refractory acute myeloid leukemia (AML) have a dismal prognosis. Chimeric antigen receptor T (CART) cell therapy has produced exciting results in CD19+ malignancies and may overcome many of the limitations of conventional leukemia therapies. We developed CART cells to target CD33...

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Veröffentlicht in:Leukemia
Hauptverfasser: Kenderian, SS, Ruella, M, Shestova, O, Klichinsky, M, Aikawa, V, Morrissette, JJD, Scholler, J, Song, D, Porter, DL, Carroll, M, June, CH, Gill, S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644600/
https://ncbi.nlm.nih.gov/pubmed/25721896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.52
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