The effects of long-term daily folic acid and vitamin B(12) supplementation on genome-wide DNA methylation in elderly subjects

BACKGROUND: Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during early development. To what extent regulation of DNA methylation can be altered vi...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Kok, Dieuwertje E. G., Dhonukshe-Rutten, Rosalie A. M., Lute, Carolien, Heil, Sandra G., Uitterlinden, André G., van der Velde, Nathalie, van Meurs, Joyce B. J., van Schoor, Natasja M., Hooiveld, Guido J. E. J., de Groot, Lisette C. P. G. M., Kampman, Ellen, Steegenga, Wilma T.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644301/
https://ncbi.nlm.nih.gov/pubmed/26568774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0154-5
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