CD32a antibodies induce thrombocytopenia and type II hypersensitivity reactions in FCGR2A mice

The CD32a immunoglobulin G (IgG) receptor (Fcγ receptor IIa) is a potential therapeutic target for diseases in which IgG immune complexes (ICs) mediate inflammation, such as heparin-induced thrombocytopenia, rheumatoid arthritis, and systemic lupus erythematosus. Monoclonal antibodies (mAbs) are a p...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Meyer, Todd, Robles-Carrillo, Liza, Davila, Monica, Brodie, Meghan, Desai, Hina, Rivera-Amaya, Mildred, Francis, John L., Amirkhosravi, Ali
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Platelets and Thrombopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644267/
https://ncbi.nlm.nih.gov/pubmed/26396093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-638684
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