Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode

BACKGROUND: Combined fatty acid amide hydrolase (FAAH) and cyclooxygenase (COX) inhibition is a promising approach for pain-relief. The Flu-AM1 and Ibu-AM5 derivatives of flurbiprofen and ibuprofen retain similar COX-inhibitory properties and are more potent inhibitors of FAAH than the parent compou...

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Publicat a:PLoS One
Autors principals: Karlsson, Jessica, Morgillo, Carmine M., Deplano, Alessandro, Smaldone, Giovanni, Pedone, Emilia, Luque, F. Javier, Svensson, Mona, Novellino, Ettore, Congiu, Cenzo, Onnis, Valentina, Catalanotti, Bruno, Fowler, Christopher J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643906/
https://ncbi.nlm.nih.gov/pubmed/26565710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142711
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