Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor

BACKGROUND: Increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile is 2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide (Flu-AM...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gouveia-Figueira, Sandra, Karlsson, Jessica, Deplano, Alessandro, Hashemian, Sanaz, Svensson, Mona, Fredriksson Sundbom, Marcus, Congiu, Cenzo, Onnis, Valentina, Fowler, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583449/
https://ncbi.nlm.nih.gov/pubmed/26406890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139212
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